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1、·傳統(tǒng)醫(yī)藥·中I虱茄2014年1月2013第23卷第2期TraditionalmedicineChinaPharmaceutic伍lsVo1.23,No.2,Janua~20,2014阿魏酸鈉聯(lián)合胰激肽原酶治療早期糖尿病腎病40例臨床觀察張玉靜,魏世錦,武玉芳,,郭更新(1.河北省邢臺市人民醫(yī)院腎內(nèi)科,河北邢臺054031;2.河北省柏鄉(xiāng)縣人民醫(yī)院檢驗(yàn)科,河北邢臺055450;3.河北省內(nèi)邱縣人民醫(yī)院內(nèi)三科,河北邢臺054200)摘要:目的觀察阿魏酸鈉聯(lián)合胰激肽原酶治療早期糖尿病腎病的臨床療效。方法將80例早期糖尿病腎病患者隨機(jī)
2、分成兩組,對照組40例,給予阿魏酸鈉注射液0.3g加入0.9%氯化鈉注射液250mL靜脈滴注,每日1次;治療組40例,在對照組基礎(chǔ)上聯(lián)合胰激肽原酶片240U口服,每日3次,治療4周。觀察兩組治療前后尿微量白蛋白排泄率(UAER)7~&清胱抑素C(CysC)的變化。結(jié)果兩組均能降低UAER及CysC水平(P<0.05),但治療組更顯著(P<0.01)。結(jié)論阿魏酸鈉聯(lián)合胰激肽原酶治療早期糖尿病腎病療效更好。關(guān)鍵詞:阿魏酸鈉;胰激肽原酶;糖尿病腎病;尿微量白蛋白排泄率;血清胱抑素c中圖分類號:R285.6;R286文獻(xiàn)標(biāo)識碼:A文章編
3、號:1006—4931(2014)02—0072—02ClinicalObservationonSodiumFerulateCombinedwithKaIlidinOgenaseforTreatingEarlyDiabeticNephropathyZhangYujing,WeiShijin,WuYufanf,GuoGengxin(.DepartmentofNephrology,XingtaiMunicipalPeople’sHospital,Xingtai,Hebei,China054031;2.DepartmentofLabo
4、ratory,BaixiangCountyPeople‘sHospital,Xingtai,Hebei,China055450;3.ThirdDepartmentoyInternalMedicine,NeiqiuCountyPeople’Hospital,Handan,Hebei,China054200)Abstract:0bjectiveToobservetheclinicaleffectofsodiumferulatecombinedwithkallidinogenaseinthetreatmentofearlydiabet
5、icnephropathy.Methods80patientswithearlydiabeticnephropathywererandomLydividedintotwogroups.40casesinthecontrolgroupweregivenSoldiumFerulateInjection0.3gin0.9%SodiumChloride250mLbyintravenousdrip.onceaday,whileonthebasisofthecontrolgroup,40casesinthetreatmentgroupwer
6、ecombinedwithoralKallidinogenaseTablet240U,threetimesaday,f0r4一weektreatment.Thechangesoftheurinaryalbuminexcretionrate(UAER)andserumcystatinC(CysC)beforeandaftertreatmentwereobservedinthetwogroups.ResultsUAERandserumCysCweredecreasedinthetwogroups(P<0.05)-hutwhichin
7、thetreatmentgroupwasmoresignificant(P<0.O1).ConclusionSodiumferulatecombinedwithkallidinogenasehasbettereffectforthetreatmentofearlydiabeticnephropathyKeywords:sodiumferulate;kallidinogenase;diabeticnephropathy;urinealbuminexcretionrate;senlmcystatinC據(jù)糖尿病的最新流行病學(xué)調(diào)查報告顯
8、示,我國20歲以上人22例,女18例;平均(54.98±6.09)歲;平均病程(9.82-4-2.71)歲。群糖尿病患病率已達(dá)9.7%,而糖尿病前期的患病率高達(dá)治療組40例,男24例,女16例;平均(53.9±10.67)歲;平均病15.5%,估計目前我國約有9