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1、NOTEVirologyDetectionofAsciticFelineCoronavirusRNAfromCatswithClinicallySuspectedFelineInfectiousPeritonitisTakehisaSOMA1)*#,MakotoWADA2,3)#,SatoshiTAHARAGUCHI4)andTomokoTAJIMA2)1)VeterinaryDiagnosticLaboratory,MarupiLifetechCo.,Ltd.,103Fushiocho,Ikeda,Osaka563–0011,Japan2)DepartmentofVeterinarySc

2、ience,GraduateSchoolofLifeandEnvironmentalSciences,OsakaPrefectureUniversity,1–58Rinku-Orai-Kita,Izumisano,Osaka598–8531,Japan3)TaniAnimalHospital,240–8Hirai,Naka-ku,Sakai,Osaka599–8251,Japan4)LaboratoryofVeterinaryMicrobiologyII,DepartmentofVeterinaryMedicine,AzabuUniversity,1–17–71Fuchinobe,Chuo

3、-ku,Sagamihara,Kanagawa252–5201,Japan(Received21February2013/Accepted15May2013/PublishedonlineinJ-STAGE29May2013)ABSTRACT.Asciticfelinecoronavirus(FCoV)RNAwasexaminedin854catswithsuspectedfelineinfectiousperitonitis(FIP)byRT-PCR.Thepositivitywassignificantlyhigherinpurebreds(62.2%)thanincrossbreds

4、(34.8%)(P<0.0001).Amongpurebreds,thepositivitiesintheNorwegianforestcat(92.3%)andScottishfold(77.6%)weresignificantlyhigherthantheaverageofpurebreds(P=0.0274and0.0251,respectively).Thepositivitywassignificantlyhigherinmales(51.5%)thaninfemales(35.7%)(P<0.0001),whereasnogenderdifferencehasgenerally

5、beennotedinFCoVantibodyprevalence,indicatingthatFIPmorefrequentlydevelopsinmalesamongFCoV-infectedcats.Genotypingwasperformedfor377gene-positivespecimens.TypeI(83.3%)wasfarmorepredominantlydetectedthantypeII(10.6%)(P<0.0001),similartopreviousserologicalandgeneticsurveys.KEYWORDS:domesticcat,effusi

6、veFIP,felinecoronavirus,Japan,RNA.doi:10.1292/jvms.13-0094;J.Vet.Med.Sci.75(10):1389–1392,2013Felineinfectiousperitonitis(FIP)isanimmune-mediatedconcerningthestateofFIPincidencehavebeenreportedprogressiveinfectiousdiseaseofdomesticcatsandwildoverseas[6,15,16,18,29].InJapan,therehavebeenseveralfeli

7、dscausedbyinfectionwithfelinecoronavirus(FCoV),reportsontheprevalenceofFCoVinfection[11,13,20,24],asingle-strandedRNAvirusclassifiedasAlphacoronavirusbut,toourknowledge,nostudiesonFIPprevalencehave[1,28].Itisdivi