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1、CHAPTER20FelineCoronavirusInfectionJaneE.Sykes3monthsto3yearsofage,withatleast50%ofaffectedcatsOverviewofFelineCoronavirusInfectionsaged12monthsoryounger(Figure20-1).However,FIPcanFirstDescribed:19631;aviraletiologywasnotidentifieduntiloccuratanyage,andthereisasec

2、ondarypeakofincidencethe1970s.ingeriatriccats(>10yearsofage),possiblyasaresultofsub-Cause:Felinecoronavirus(FamilyCoronaviridae,genusoptimalimmunefunction.MalesandsexuallyintactcatshaveCoronavirus)beenpredisposedinsomestudies,9-11andadiseasepeakmayexistinthefallan

3、dwinter.12AlthoughthediseaseoccursinAffectedHosts:Catsandwildfelids,especiallycheetahsallbreeds,purebredcatsaremoresusceptible;Abyssinians,ModeofTransmission:Fecal-oralAustralianmist,Bengals,birmans,Burmese,Britishshorthairs,GeographicDistribution:WorldwideHimalay

4、ans,ragdolls,rexes,andpossiblyScottishfoldsmaybepredisposed.9-14Breedpredispositionsmayvarygeographi-MajorClinicalSigns:Fever,lethargy,inappetence,vomiting,callyandtemporallydependingonthepreferencesofbreedersdiarrhea,dehydration,icterus,tachypnea,uveitis,neuro-in

5、aregion,andspecificlinesmaybemorepredisposedthanthelogicsigns,abdominaldistentionduetoascites.6breedsthemselves.ThemolecularbasisofgeneticsusceptibilityDifferentialDiagnoses:Toxoplasmosis,congestivehearttoFIPiscurrentlyunclear.SiblingsofcatsthatdieofFIPmayfailure,

6、carcinomatosis,lymphoma,pancreatitis,rabies,beatincreasedriskforFIP.15cryptococcosis,bacterialperitonitis,pyothorax,bacterialInmultiple-cathouseholdsituations,catsarerepeatedlymeningitis,chronicstomatitis,multiplemyeloma,infec-infected,shedvirus,andrecover,butsome

7、catsremainpersis-tionwithFeLVorFIV.tentlyinfectedandchronicallyshedFCoVintheabsenceofclini-calsigns(Figure20-2).Morethanhalf,andasmanyas100%ofHumanHealthSignificance:Felinecoronavirusesdonotcatsinenvironmentswithmorethansixcats,becomeinfectedinfecthumans.withFCoVs

8、.6Theseroprevalenceislowerincatsfromsingle-cathouseholdsandamongferalcats.16However,eventhoughtheprevalenceofinfectioninmulticathouseholdsishigh,fewerth