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《FICLIL-2基因RS785 1696多態(tài)性相關(guān) Delayed Graft功能與腎臟急性排斥反應(yīng) 同種異體移植受者》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、Arch.Immunol.Ther.Exp.(2018)66:65–72https://doi.org/10.1007/s00005-017-0475-5ORIGINALARTICLEFicolin-2Geners7851696PolymorphismisAssociatedwithDelayedGraftFunctionandAcuteRejectioninKidneyAllograftRecipients121,2EwaDabrowska-Zamojcin?MichalCzerewaty?DamianMalinowski?2
2、23MaciejTarnowski?SylwiaS?uczanowska-G?abowska?LeszekDomanski?42KrzysztofSafranow?AndrzejPawlikReceived:9February2017/Accepted:6April2017/Publishedonline:23May2017óTheAuthor(s)2017.ThisarticleisanopenaccesspublicationAbstractFicolin-2isanactivatorofthecomplementsigni
3、?cantlyhigherinpatientswithAR(TvsGOR1.71,systemthatactsviathelectinpathway.Complementacti-95%CI1.02–2.87,p=0.048).Theresultsofourstudyvationplaysasubstantialroleintherenalinjuryinherenttosuggestthat?colin-2rs7851696genepolymorphismkidneytransplantation.Inthisstudy,we
4、examinedthein?uenceskidneyallograftfunctions,withTalleleassociationsbetween?colin-2genepolymorphismsinexonincreasingtheriskofDGFandAR.8andkidneyallograftfunction.Thisstudycomprised270Caucasiandeceased-donorrenaltransplantrecipients.TheKeywordsDiabetesTransplantation
5、followingparameterswererecordedineachcase:delayedSingle-nucleotidepolymorphismGenePolymorphismsgraftfunction(DGF),acuterejection(AR),andchronicallograftdysfunction.AmongpatientswithDGF,weobservedasigni?cantlyincreasedfrequencyofrs7851696IntroductionGTandTTgenotype
6、saswellasTallele(TT?GTvsGGOR1.98,95%CI1.12–3.48,p=0.02;TvsGOR2.08,Kidneytransplantationisacommonlyusedtherapyfor95%CI1.27–3.41,p=0.005).Therewasalsoanchronickidneydiseases.Unfortunately,kidneytransplan-increasedfrequencyofrs4521835GGandTGgenotypesastationisassociated
7、withseveralcomplicationsaffectingwellasGalleles;however,thesedifferenceswereonthegraftfunction.Especiallyprevalentamongthesecompli-borderlineofstatisticalsigni?cance(GG?TGvsTT,ORcationsaredelayedgraftfunction(DGF),acuterejection1.75,95%CI0.98–3.12,p=0.07;GvsTOR1.45,9
8、5%(AR),andchronicallograftdysfunction(CAD).GraftCI1.00–2.09,p=0.050).Inaddition,weobservedantransplantationinducesseveralchangesint
