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1、第30卷第4期哈爾濱商業(yè)大學(xué)學(xué)報(bào)(自然科學(xué)版)v。1．30N。．42014年8月JournalofHarbinUniversi1yofCommerce(NaturalSciencesEdition)Aug．2014Ⅱ型糖尿病患者認(rèn)知功能障礙危險(xiǎn)因素分析王凱亮，張軍，韓嚦，李洪梅(北京市煤炭總醫(yī)院內(nèi)分泌科，北京100028)摘要：探討Ⅱ型糖尿病患者輕度認(rèn)知功能障礙(MCI)的相關(guān)危險(xiǎn)因素．將165例Ⅱ型糖尿病患者根據(jù)MoCA北京版量表分為Ⅱ型糖尿病認(rèn)知功能障礙組95例及Ⅱ型糖尿病認(rèn)知功能正常組7O例．比較兩組的臨床資料，進(jìn)行非條件Logistic回歸分析認(rèn)知功能障礙的相關(guān)危險(xiǎn)因素．

2、與對(duì)照組比較，MCI組較對(duì)照組糖尿病病程長(zhǎng)(P<0．05)，Hb／Ic、空腹胰島素水平、TC、LDL—C水平、同型半胱氨酸水平、尿微量白蛋白明顯高于對(duì)照組(P<0．05)；兩組間BMI、空腹血糖、餐后2h血糖、TG、HDL—C、肌酐、血尿酸、收縮壓、舒張壓間差異無(wú)統(tǒng)計(jì)學(xué)意義．非條件Logistic回歸分析結(jié)果顯示高齡、血糖控制不佳、糖尿病病程長(zhǎng)、高血壓病史、糖尿病腎病、糖尿病周?chē)窠?jīng)病變均是Ⅱ型DM合并認(rèn)知功能障礙的獨(dú)立危險(xiǎn)因素．早期診斷有助于預(yù)防和減少認(rèn)知功能障礙的發(fā)生．關(guān)鍵詞：11型糖尿??；認(rèn)知功能障礙中圖分類(lèi)號(hào)：R285文獻(xiàn)標(biāo)識(shí)碼文章編號(hào)：1672—0946(2014)04

3、—0405—04Studyoncognitivedysfunctionandanalysisofriskfactorofpatientswithtype—-lIdiabetesmellitusWANGKai—liang，ZHANGJun，HANYang，LIHong—met(BranchofEndocrinology，BeijingGeneralHospitalofCoal，Beijing100028，China)Abstract：Toinvestigatetheriskfactorsofmildcognitiveimpairment(MCI)inpatientswithtype

4、IIdiabetes(T2DM)，atotalof165T2DMpatientsweredividedintoT2DMwithMCIgroup(n：95)andT2DMwithnormalcognitivefunction(NMCI)group(=70)．Montre-alcognitiveassessmentscale(MoCA)、Arasusedtoassessthefunctionalstatusintwogroupsofpatients．Nonconditionlogsticregressionwasusedtoanalyzetherelatedfactorsofcogn

5、i—tivedysfunction．Comparedwiththecontrolgroup，thediabetescourse，bloodlevelsofHbAIc，fastinginsulin，totalcholesterol，low—densitylipoprotein～cholesterol，homocysteicacid，andmicrourineproteinsignificanllyincreased．TherewerenosignificantdifferencesinBMI，fastingbloodglucose，postprandial2hbloodsugar，

6、triglycerides，highdensitylipo—protein—cholesterol，creatinine，blooduricacid，contractivepressure，anddiastolicbloodpressurebetweenthetwogroups．Muhipleregressionanalysisshowedthatolderage，ineffi—cientcontrolofbloodglucose，longdurstionofdiabetesmellitus，historyofhypertension，di—abeticnephropathy，a

7、nddiabeticperine。uropathyweresignificantlyindependentdeterminantf0rtheT2DMwithcognitivedysfunction．ManyriskfactorsmayplayapartinT2DMwithMCI．EarlydetectionandpromptingmedicalattentionmayhelppreventanddecreasetheprevalenceofMCIinpatientswithT2D