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1、F1000Research2017,6(F1000FacultyRev):1628Lastupdated:01SEP2017REVIEWOriginsandpathogenesisofMiddleEastrespiratorysyndrome-associatedcoronavirus:recentadvances[version1;referees:3approved]Stephen?A.?Goldstein,Susan?R.?WeissDepartment?of?Microbiology,?Perelman?School?of?Medicine,?Univ

2、ersity?of?Pennsylvania,?Philadelphia,?PA,?USAv1Firstpublished:?01?Sep?2017,?6(F1000?Faculty?Rev):1628?(doi:?OpenPeerReview10.12688/f1000research.11827.1)Latestpublished:?01?Sep?2017,?6(F1000?Faculty?Rev):1628?(doi:?10.12688/f1000research.11827.1)RefereeStatus:AbstractInvited?Referee

3、sMiddle?East?respiratory?syndrome-associated?coronavirus?(MERS-CoV)?has123been?a?significant?research?focus?since?its?discovery?in?2012.?Since?2012,?2,040cases?and?712?deaths?have?been?recorded?(as?of?August?11,?2017),version1representing?a?strikingly?high?case?fatality?rate?of?36%.

4、?Over?the?last?severalpublishedyears,?MERS-CoV?research?has?progressed?in?several?parallel?and01?Sep?2017complementary?directions.?This?review?will?focus?on?three?particular?areas:?theorigins?and?evolution?of?MERS-CoV,?the?challenges?and?achievements?in?thedevelopment?of?MERS-CoV?an

5、imal?models,?and?our?understanding?of?howF1000?Faculty?Reviews?are?commissionednovel?proteins?unique?to?MERS-CoV?counter?the?host?immune?response.?Thefrom?members?of?the?prestigious?F1000origins?of?MERS-CoV,?likely?in?African?bats,?are?increasingly?clear,?althoughFaculty.?In?order?t

6、o?make?these?reviews?asimportant?questions?remain?about?the?establishment?of?dromedary?camels?as?acomprehensive?and?accessible?as?possible,reservoir?seeding?human?outbreaks.?Likewise,?there?have?been?importantadvances?in?the?development?of?animal?models,?and?both?non-human?primatepe

7、er?review?takes?place?before?publication;?theand?mouse?models?that?seem?to?recapitulate?human?disease?are?now?available.referees?are?listed?below,?but?their?reports?areHow?MERS-CoV?evades?and?inhibits?the?host?innate?immune?response?remainsnot?formally?published.less?clear.?Although

8、?several?studies?ha