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1、AcceptedManuscriptTheroleofepidermalgrowthfactorreceptor(EGFR)signalinginSARScoronavirus-inducedpulmonaryfibrosisThiagarajanVenkataraman,MatthewB.FriemanPII:S0166-3542(16)30797-5DOI:10.1016/j.antiviral.2017.03.022Reference:AVR4042Toappearin:AntiviralResearchReceivedDate:20

2、December2016AcceptedDate:28March2017Pleasecitethisarticleas:Venkataraman,T.,Frieman,M.B.,Theroleofepidermalgrowthfactorreceptor(EGFR)signalinginSARScoronavirus-inducedpulmonaryfibrosis,AntiviralResearch(2017),doi:10.1016/j.antiviral.2017.03.022.ThisisaPDFfileofanuneditedma

3、nuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybe

4、discoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTTheRoleofEpidermalGrowthFactorReceptor(EGFR)SignalinginSARSCoronavirus-InducedPulmonaryFibrosisThiagarajanVenkataramanandMatthewBFrieman*DepartmentofMicrobiologyandImm

5、unologyUniversityofMarylandatBaltimore685WestBaltimoreSt.Room380Baltimore,MD21201MANUSCRIPT*CorrespondingauthorMatthewFriemanUniversityofMarylandatBaltimoreDepartmentofMicrobiologyandImmunology685WestBaltimoreSt.Room380Baltimore,MD21201mfrieman@som.umaryland.edu/410-706-25

6、39ACCEPTEDKeywords:Woundhealing,SARS-CoV,EGFR,fibrosisACCEPTEDMANUSCRIPTAbstractManysurvivorsofthe2003outbreakofsevereacuterespiratorysyndrome(SARS)developedresidualpulmonaryfibrosiswithincreasedseverityseeninolderpatients.AutopsiesofpatientsthatdiedfromSARSalsoshowedfibro

7、sistovaryingextents.PulmonaryfibrosiscanbeoccasionallyseenasaconsequencetoseveralrespiratoryviralinfectionsbutismuchmorecommonafteraSARScoronavirus(SARS-CoV)infection.Giventhethreatoffutureoutbreaksofseverecoronavirusdisease,includingMiddleEastrespiratorysyndrome(MERS),iti

8、simportanttounderstandthemechanismsresponsibleforpulmonaryfibrosis,soastosupportthedevelo