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1、OThe?ncologistLungCancerAssessmentofEpidermalGrowthFactorReceptorandK-RasMutationStatusinCytologicalStainedSmearsofNon-SmallCellLungCancerPatients:CorrelationwithClinicalOutcomesabacbMARIAD.LOZANO,JAVIERJ.ZULUETA,JOSEI.ECHEVESTE,ALFONSOGúRPIDE,LUISM.SEIJO,ccdaSALV

2、ADORMARTíN-ALGARRA,ANABELDELBARRIO,RUBENPIO,MIGUELANGELIDOATE,acTANIALABIANO,JOSELUISPEREZ-GRACIAabcDepartmentofPathology,DepartmentofRespiratoryMedicine,andDepartmentofOncology,dUniversityofNavarraClinic,andDepartmentofBiochemistryandDivisionofOncology,CentreforA

3、ppliedMedicalResearch,UniversityofNavarra,Pamplona,SpainKeyWords.Carcinoma?Non-smallcelllung?Cytology?Papanicolaustainedsmears?Mutations?Epidermalgrowthfactorreceptor–neureceptor?Genes?Ras?Erlotinib?GefitinibDisclosures:MariaD.Lozano:None;JavierJ.Zulueta:Ownership

4、interest:VisionGate,Inc.;JoseI.Echeveste:None;AlfonsoGúrpide:None;LuisM.Seijo:None;SalvadorMartín-Algarra:None;AnabeldelBarrio:None;RubenPio:None;MiguelAngelIdoate:None;TaniaLabiano:None;JoseLuisPerez-Gracia:None.Thecontentofthisarticlehasbeenreviewedbyindependent

5、peerreviewerstoensurethatitisbalanced,objective,andfreefromcommercialbias.Nofinancialrelationshipsrelevanttothecontentofthisarticlehavebeendisclosedbytheindependentpeerreviewers.ABSTRACTObjective.Epidermalgrowthfactorreceptor(EGFR)Results.Thecytologicaldiagnosiswa

6、sadenocarcinomaandK-rasmutationsguidetreatmentselectioninnon-in110samples(73%)andnonadenocarcinomain40smallcelllungcancer(NSCLC)patients.Althoughmu-(27%)samples.EGFRmutationswereidentifiedin26tationstatusisroutinelyassessedinbiopsies,cytologicalsamples(17%)andK-ra

7、smutationswereidentifiedin18specimensarefrequentlytheonlysamplesavailable.(12%)samples.EGFRandK-rasmutationsweremutuallyWedeterminedEGFRandK-rasmutationsincytologi-exclusive.InEGFR-mutatedcases,DNAwasobtainedcalsamples.fromstainedsmearsin24cases(92%),pleuralfluidi

8、noneMethods.DNAwasextractedfrom150consecutivecase(4%),andcellblockinonecase(4%).Theresponsesamples,including120Papanicolausmears(80%),10cellratetoEGFRTK