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1、AcceptedManuscriptStructuralmodeloftheSARScoronavirusEchannelinLMPGmicellesWahyuSurya,YanLi,JaumeTorresPII:S0005-2736(18)30058-0DOI:doi:10.1016/j.bbamem.2018.02.017Reference:BBAMEM82711Toappearin:Receiveddate:1November2017Reviseddate:14February2018Accepteddate:16February2018Pleasecitethisarticleas:W

2、ahyuSurya,YanLi,JaumeTorres,StructuralmodeloftheSARScoronavirusEchannelinLMPGmicelles.Theaddressforthecorrespondingauthorwascapturedasaffiliationforallauthors.Pleasecheckifappropriate.Bbamem(2018),doi:10.1016/j.bbamem.2018.02.017ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.A

3、saservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplyto

4、thejournalpertain.ACCEPTEDMANUSCRIPTStructuralmodeloftheSARScoronavirusEchannelinLMPGmicellesWahyuSurya,YanLiandJaumeTorresSchoolofBiologicalSciences;NanyangTechnologicalUniversity;60NanyangDrive,Singapore637551;Singapore.*Correspondence:JaumeTorres(E-mail:jtorres@ntu.edu.sg;Tel.:+65-6316-2857;Fax:+

5、65-6791-3856)ABSTRACTCoronaviruses(CoV)causecommoncoldsinhumans,butarealsoresponsiblefortherecentSevereAcute,andMiddleEast,respiratorysyndromes(SARSandMERS,respectively).Apromisingapproachforpreventionareliveattenuatedvaccines(LAVs),someofwhichtargettheenvelope(E)protein,whichisasmallmembraneprotein

6、thatformsionchannels.Unfortunately,detailedstructuralinformationisstilllimitedforSARS-CoVE,andnon-existentforotherCoVEproteins.Herein,wereportastructuralmodelofaSARS-CoVEconstructinLMPGmicelleswith,forthefirsttime,unequivocalintermolecularNOEs.Themodelcorrespondingtothedetergent-embeddedregioniscons

7、istentwithpreviouslyobtainedorientationalrestraintsobtainedinlipidbilayersandinvivoescapemutants.TheC-terminaldomainismostlyα-helical,andeACCEPTEDMANUSCRIPTxtramembraneintermolecularNOEssuggestinterac