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1、CURRENTABSTRACTSEditedby:RobertJ.Leggiadro,MDhighdose
-lactamadministration,neuromuscularblockadeofami-NonantimicrobialEffectsofAntibacterialAgentsnoglycosides,dysglycemiaof?uoroquinolonesandserotoninsyn-R.PasqualeandJ.Tan.ClinInfectDis2005;40:127–135dromewithoxazolidinon

2、es.Thenonantimicrobialtherapeuticactivitiesderivedfromknownsideeffectsofantimicrobialagentsarereviewed.Forexample,sulfon-amide-relatedagentsthatlackantimicrobialactivityarecommonlyTularemiaAssociatedwithaHamsterBite:Colorado,2004usedforhypoglycemiceffect(sulfonylureas)and

3、carbonicanhy-CentersforDiseaseControlandPrevention.MMWR.2005;53:draseblockade(acetazolamide).1202–1203.Nonantibacterialeffectsofmacrolidesincludegastrointesti-TheColoradoDepartmentofPublicHealthandEnvironmentwasnalmotilityandimmunomodulation.Clinicalstudiessuggestthatnoti

4、?edabouta3-year-oldboydiagnosedwithtularemiaassociatederythromycinandother14-membermacrolidesactasmotilinrecep-withapethamster.Sixhamstersthathisfamilyhadpurchasedfromtoragonists.Motilin,anaminoacidpeptide,isbelievedtoplayaapetstoreintheDenvermetropolitanareaduringthewint

5、erof2004roleincontrollingthecyclicburstsofcontractileactivitythatoccurdiedwithin1weekofpurchase.Onehamsterbitthechildontheleftinthegastrointestinaltractduringthefastingstate.Erythromycinring?ngershortlybeforeitdied.Thechilddevelopedfever,malaise,andothermacrolidesalsohave

6、bene?cialimmunomodulatoryef-painfulleftaxillarylymphadenopathyandskinsloughingatthebitefects.Theseantibioticshavebeenfoundtobebene?cialinthesite7dayslater.Tissuecultureofaleftaxillarylymphnodetreatmentofhypersecretoryconditions,suchasdiffusepanbronchi-excisionalbiopsyspec

7、imenyieldedaFrancisellatularensisisolate,olitisandcystic?brosis.andconvalescentserologywaspositiveatatiterof4096.ThepatientAlthoughthemechanismbywhichmacrolidesareeffec-improvedaftertreatmentwithcipro?oxacin.Nootherriskfactorstiveinthetreatmentofhypersecretoryconditionsis

8、notcom-fortularemiaexposurewereidenti?ed,includingnootheranimalpletelyunderstood,severaltheories