《Vitamin D Beyond Bones in Chronic ObstructivePulmonary Disease慢性阻塞性骨骼以外的維生素D 肺部疾病》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、PulmonaryPerspectiveVitaminDBeyondBonesinChronicObstructivePulmonaryDiseaseTimetoActWimJanssens1,AnLehouck1,ClaudiaCarremans1,RogerBouillon2,ChantalMathieu2,andMarcDecramer112RespiratoryDivision,UniversityHospitalGasthuisberg;andClinicandLaboratoryofExp

2、erimentalMedicineandEndocrinology,KatholiekeUniversiteitLeuven,Leuven,BelgiumThediscoverythatthevitaminDendocrinesystemregulatesaveryful?lledtheirpromises.Inviewofthedisappointingresultsoflargenumberofgenesandtheirassociatedbiologicalprocessesthesespeci

3、?candexpensivedrugs,moreattentionshouldbeimprovesourinsightintothefundamentalroleofvitaminDandsunrefocusedonthepotentialofolderdrugsinnewindications.exposureforhumanhealth.AccumulatingepidemiologicaldataareStatins,angiotensin-convertingenzyme(ACE)–inhib

4、itors,andlinkingalowvitaminDnutritionalstatustohighlyprevalentdiseasesheparinesallhaveabroader?eldofactionthaninitiallypre-suchascancer,autoimmunediseases,andchronicinfections.Ap-sumedandmaybecomeofinterestinthefuturetherapyofproximatelyhalfoftheworldse

5、lderly,andtoalesserextenttheCOPD(3,4).Inthisperspectivewewilldiscussthepotentialofadultpopulation,haveinsuf?cienttode?cient25-hydroxyvitaminDanother,evenoldermolecule,vitaminD.(25-OHD)serumlevels,andseveralinterventionstudiesarebeingAfterthedualoriginof

6、vitaminD(bysynthesisintheskinorundertakentostudytheimpactofadequatevitaminDsupplemen-bydietaryintake)wasunderstood,oralvitaminDsupplemen-tationinchronicdiseases.Inthisperspectiveweclaimthatchronictationalmostfullyeradicatedendemicrickets.Manyhealthobstr

7、uctivepulmonarydisease(COPD)isacandidatediseaseforcareprofessionalsthoughtthemajorhealthproblemsresultingwhichvitaminDsupplementationmightbebene?cial.Epidemio-fromvitaminDde?ciencyhadthusbeenresolved.However,logicalstudiesrevealedadose-dependentassociat

8、ionbetweenserum25-OHDlevelsandpulmonaryfunctionsothatadequateitturnedoutthatricketswasonlythetopoftheicebergandvitaminDsupplementationmayextendbeyonditsprotectionthatlessseverevitaminDde?ciencyisstillverycommonandagainstosteoporo