《Preparation characterization and pharmacokinetic studies of linalool loaded nanostructured lipid carriers制備、表征及 芳樟醇負(fù)荷的藥代動(dòng)力學(xué)研究 納米結(jié)構(gòu)脂質(zhì)載體》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。

1、PharmaceuticalBiologyISSN:1388-0209(Print)1744-5116(Online)Journalhomepage:http://www.tandfonline.com/loi/iphb20Preparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriersFengShi,YingyingZhao,CalebKesseFirempong&XimingXuTocitethisarticle:

2、FengShi,YingyingZhao,CalebKesseFirempong&XimingXu(2016)Preparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriers,PharmaceuticalBiology,54:10,2320-2328,DOI:10.3109/13880209.2016.1155630Tolinktothisarticle:https://doi.org/10.3109/13880209

3、.2016.1155630Publishedonline:17Mar2016.SubmityourarticletothisjournalArticleviews:504ViewCrossmarkdataCitingarticles:4ViewcitingarticlesFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=iphb20PHARMACEUTICALBIOLOGY,2

4、016VOL.54,NO.10,2320–2328http://dx.doi.org/10.3109/13880209.2016.1155630RESEARCHARTICLEPreparation,characterizationandpharmacokineticstudiesoflinalool-loadednanostructuredlipidcarriersFengShi*,YingyingZhao*,CalebKesseFirempongandXimingXuDepartmentofPharmaceutics,SchoolofPharm

5、acyCenterforNanoDrug/GeneDeliveryandTissueEngineering,JiangsuUniversity,Zhenjiang,PRChinaABSTRACTARTICLEHISTORYContextLinalool(LL)isassociatedwithnumerouspharmacologicalactivities.However,itspoorsolubilityReceived15August2015usuallyresultsinpoorbioavailability,andfurtherlimit

6、editsapplications.Accepted13February2016ObjectiveToreducevolatilizationandimprovebioavailabilityofLL,linalool-loadednanostructuredlipidPublishedonline15Marchcarriers(LL-NLCs)wereprepared.2016MaterialsandmethodsLL-NLCswerepreparedusinghigh-pressurehomogenizationmethodandopti-K

7、EYWORDSmizedviaresponsesurfacemethodology-centralcompositedesign,followedbycharacterization,includingEssentialoil;high-pressureparticlesize(PS),zetapotential(ZP),transmissionelectronmicroscope(TEM),X-raydiffraction(XRD),differ-homogenization;response1entialscanningcalorimetr

8、y(DSC)andinvitroreleasestudy.Ratswereadministered300mgkgLLsurfaceme