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1、MicrobialEcologyinHealthandDiseaseISSN:(Print)1651-2235(Online)Journalhomepage:http://www.tandfonline.com/loi/zmeh20GeneTransferintheGITractandOralCavityPeterMullanyTocitethisarticle:PeterMullany(2000)GeneTransferintheGITractandOralCavity,MicrobialEcologyinHea

2、lthandDisease,12:2,73-80,DOI:10.1080/089106000750060323Tolinktothisarticle:https://doi.org/10.1080/089106000750060323?2000TheAuthor(s).PublishedbyTaylor&Francis.Publishedonline:11Jul2009.SubmityourarticletothisjournalArticleviews:16FullTerms&Conditionsofaccess

3、andusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=zmeh20ORIGINALARTICLEGeneTransferintheGITractandOralCavityPeterMullanyFromtheDepartmentofMicrobiology,EastmanDentalInstitute,UniversityofLondon,256GraysInnRoad,LondonWC1X8LD,UKC

4、orrespondenceto:PeterMullany,DepartmentofMicrobiology,EastmanDentalInstitute,UniversityofLondon,256GraysInnRoad,LondonWC1X8LD,UK.Tel:?44(0)2079151223;Fax:?44(0)2079151127;E-mail:p.mullany@eastman.ucl.ac.ukMicrobialEcologyinHealthandDisease2000;Suppl2:73–80Gene

5、transferisimportantinspreadingantibioticresistanceandothertraitssuchasvirulencefactors.InthisreviewthemolecularmechanismsofgenetransferareoutlinedandthebiologicalconsequencesofbacterialgenetransferintheGItractandtheoralcavity(GIOC)arediscussed.Finallyareasofpo

6、ssiblefutureresearchaimedatattainingadeeperunderstandingoftheprocessofgenetransferandthepotentialforstoppingorslowingunwantedtransferarediscussed.Keywords:genetransfer,conjugation,conjugativetransposons,mobilegeneticelements.INTRODUCTIONothermobileelements(non

7、conjugativetransposons,inte-grativeplasmids,mobileintronsandISsequences)canGenetransferisimportantinspreadingantibioticresis-tanceandothertraitssuchasvirulencefactors.BoththeintegrateintotheconjugativeelementandbetransferredGItractandtheoralcavity(GIOC)contain

8、alargeandwiththeconjugalormobilisableelement.Someofthesediversecommunityofmicro-organisms.Althoughthebac-mobilegeneticelementshavealsobeenusedastoolsforteriainbothsitesareconsidere