《Genetic and Environmental Influences on Regional BrainUptake of 18F-FDG A PET Study on Monozygoticand Dizygotic Twins遺傳和環(huán)境對區(qū)域腦的影響 18F-FDG攝?。簡魏献拥腜ET研究 雙卵雙胎》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、Downloadedfromjnm.snmjournals.orgbySNMheadquartersonMarch1,2016.Forpersonaluseonly.GeneticandEnvironmentalIn?uencesonRegionalBrainUptakeof18F-FDG:APETStudyonMonozygoticandDizygoticTwinsShinichiroWatanabe*1,HirokiKato*1,EkuShimosegawa1,2,andJunHatazawa1,31DepartmentofNuclearMedicineandTracerKin

2、etics,OsakaUniversityGraduateSchoolofMedicine,Osaka,Japan;2DepartmentofMolecularImaginginMedicine,OsakaUniversityGraduateSchoolofMedicine,Osaka,Japan;and3CenterforTwinResearch,OsakaUniversityGraduateSchoolofMedicine,Osaka,JapanrelatedchangesduringdevelopmentandagingandsexdifferencesGeneticoren

3、vironmentalin?uencesoncerebralglucosemetabo-inbrainglucosemetabolismhavebeenreported(3–7).Therest-lismareunknown.Weattemptedtorevealthesein?uencesining-statemetabolicnetworkhasbeenexaminedinhealthyvolun-elderlytwinsbymeansof18F-FDGPET.Methods:18F-FDGuptaketeers(8–10).However,factorsin?uencingv

4、ariationsincerebralwasstudiedin40monozygoticand18dizygoticvolunteertwinpairsmetabolismitselfhavenotbeenpreciselyinvestigatedyet.Theaged30yorover.Wealsocreated18controlpairsbypairingage-patternsofglucosemetabolisminthebrainappeartobein?u-andsex-matchedgeneticallyunrelatedsubjectsfromdizygotican

5、dencedbyvariousfactors,includinggeneticandenvironmentalmonozygoticpairs.SUVimagesofthebrainwerereconstructedfactors.However,themagnitudeandproportionofthesein?u-andanalyzedbyvoxel-basedstatisticalanalysiswithautomated18encesremainunknown.region-of-interestsetting.TheF-FDGuptakeineachcerebrallo

6、bewassemiquanti?edbytakingaratioofSUVmeanineachregionofThetwinmethodhasbeenusedtoestimatetheextentofgeneticinteresttowhole-brainSUVaverage.Wecalculatedanintraclasscor-andenvironmentalin?uenceonassociationsamongmultiplerelationcoef?cientofSUVratioineachregionofinterestformono-observedvariables(

7、11).Althoughthetwinmethodhasbeenusedzygoticanddizygoticpairs.Bycomparingdifferencesincoef?cientsmainlyinthe?eldofbehavioralgenetics,itisalsoapplicabletobetweenmonozygoticanddizygoticpairs,geneticandenvironmen-nonbehavioraltraits.Twinsar