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1、炎癥性腸病的臨床和病理特征分析陳速李彥鵬黃愛(ài)軒尹少芳廣東省東莞市寮步醫(yī)院廣東東莞523400【摘要】目的回顧性分析炎癥性腸病(IBD)的病理特征及其臨床診斷符合率,為提高IBD的診斷水平提供依據(jù).方法按照2007年中華醫(yī)學(xué)會(huì)消化病學(xué)分會(huì)IBD診治標(biāo)準(zhǔn)，選取1998至2014年木院住院230例IBD患者作為研究對(duì)象，分為潰瘍性結(jié)腸炎(UC,n=180)和克羅恩病(CD,n=50)兩組,回顧UC和UC的病理特征并進(jìn)行統(tǒng)計(jì)學(xué)分析?結(jié)果UC組病理檢查診斷符合率為34.3%,CD組病理檢查診斷符合率為29.5%，兩者差異無(wú)顯著性(p>0.05);UC組病理檢查率為

2、50.8%,CD組病理檢查率為70?2%，前者明顯低于后者(pV0?05);UC組主要病理表現(xiàn)，按發(fā)生率從高到低，依次為隱窩炎及隱窩膿腫、糜爛與潰瘍、杯狀細(xì)胞減少、腺體增牛、基底漿細(xì)胞增多、隱窩扭曲與分支、不典型增生、隱駕萎縮、絨毛狀表面;CD組依次為急慢性炎癥、非干酪樣肉芽腫、裂隙樣潰瘍?結(jié)論IBD臨床診斷中進(jìn)行病理檢查例數(shù)較少，診斷符合率偏低;UC病理特征以糜爛或潰瘍及隱窩炎與隱窩膿腫為主,CD病理特征以非干酪樣肉芽腫與裂隙樣潰瘍?yōu)橹?提示明確IBD的病理特征有利于提高IBD的診斷符合率.【關(guān)鍵詞】潰瘍性結(jié)腸炎；克羅恩??；病理Analysisonpa

3、thologicalcharacteristicsanddiagnosisofinflammatoryboweldiseaseChenSuLiYanpengHuangAixuanYinChuangfaYinShaofang(DepartmentofPaGthology,LiaobuHospital,Dongguan,Guangdong,523400)[Abstract】ObjectiveToanalysisonpathologicalcharactersandclinicaldiagnosisofinflammatoryboweldisease(IBD)

4、retrospectivelyinordertoprovidethebasistoimGprovethelevelofdiagnosisofIBD.MethodsAccordingtothe2007ChineseMedicalAssociationstandardIBDinthediagnosisandtreatmentofdigestivedisease,230casesofhospitalizedIBDpatientsfrom2000to2014inourhospitalwereselectedastheresearchobjectanddivide

5、dintotwogroupssuchasForulcerativecolitis(UC,n=180)andCrohn'sdisease(CD,n=50)?ThepathologicalcharacteristicsandclinicaldiagnosisofIBDwerereviewedandstatisticallyanalyzed.ResultsThepathologydiagnosiscoincidencerateinUCandCDwere24?4%and27.5%respectively,thedifferencebetweenthemisnot

6、significant(p>0.05).TheCDgrouppathologicalexaminationrate(70?2%)washighersignificantlythanthat(50.8%)ofUCgroup(p<0?05).ThemainpathologicalfeaturesofUCgroup,accordingtotheoccurrenceratefromhightolow,werecryptitisandcryptabscess,erosionorulcecgobletcellsreduction^landhyperplasia,ba

7、salplasmacytosis,cryptaetwistingandbranching,atypicalhyperplasiain,cryptaeatrophy,fluffinesssurfaces.ThemicroscopicmanifestationsofCDgroupincludedactivechronicinflammation’non——caseatinggranulomaandfissuringulcer.ConclusionsThenumberofcasesundergoingpathologicalexaminationwasnotv

8、eryhigh,andthecoincidenceratewaslow.Path