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1、ThesiRNAtreatmentforcancerAbstract:SmallinterferingRNA?(siRNA),alsoknownas?shortinterferingRNA,playsanimportantroleinthe?RNAinterference?pathway,whereitinterfereswiththe?expression?ofspecificgeneswithcomplementarynucleotidesequence.Inrecentyears,siRNAhasprovidedapromisingthe

2、rapeuticmodalityforthetreatmentofcancer.?Thus,thisarticlewillprovideanoverviewoftheinhibitoryeffectexertedbysiRNAonvariouskindsofcancer.ItalsodescribesthesynergisticeffectofsiRNAandothertherapy.Finally,thedeliverysystemofsiRNAwillbediscussedaswell.Keywords:siRNA,cancer,treat

3、ment,combinedtherapy,deliverysystemIntroduction:SmallinterferingRNA(siRNA)isakindofnon-codingdouble-strandedRNAs21–25nucleotidesinlengthwhichcaneffectivelyinhibitthetranslationoftargetmRNAsbybindingtotheir3′-UTRthroughspecificcleavageofperfectlycomplementarymRNA[1].Thus,siRN

4、Aisonekindofthe?RNAinterference?(RNAi)pathway.TherehasrecentlybeenanincreasinginterestinharnessingsiRNAtodevelopnoveltreatmentofvariousdiseases,suchascancer,neurologicaldisorders,age-relatedmaculardegenerationandviralinfections[2].?Amongthem,siRNAshavedisplayedconsiderablepr

5、omiseforthetreatmentof?cancerbecausesiRNAhasdistinctadvantagesoverconventionalsmallmoleculeorprotein-baseddrugs,includinghighspecificity,higherpotencyandreducedtoxicity[2].?Therefore,thisreviewwillfocusedprimarilyontheresearchesaboutthesiRNAtreatmentfordifferentkindsofcancer

6、.Secondly,areviewofthetherapieswhichcombinesiRNAandconventionalcancerdrugwillbepresentinthisarticle.Moreover,thedeliveryofsiRNAwillbediscussedaswell.siRNAcanbeanoveltreatmentofcancer:NumberousresearcheshavedemonstratedthatsiRNAcouldbeapotentialeffectivetreatmentforcancer.Tab

7、le1hassummarizedtherepressiveeffectofsiRNAtargetingdifferentgenesonvarioussortsofcancer.Fromtable1,wecanseethatsiRNAcaninhibittumorcellviabilityandproliferation.Moreover,siRNAperformsthefunctionofinducingapoptosisandreversingmultidrugresistance.Table1TreatmentofsiRNAfordiffe

8、rentsortsofcanceryearsmortgagehousing;4.mortgageregistrationformalitiesarec