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1、$10JournalofClinicalVirology2006,Vol36(suppl2)Abstracts,9thESCVAnnualMeetingI~Epidemiologyofrespiratorycoronaviruses(HCoV)ina1EarlyevolutionofhepatitisCvirus(HCV)quasispeciesDutchuniversityhospitalafterlivertransplantationH.G.M.Niesters1*,A.van'tVeen1,2,M.Schutten1,S.Pas1,ES

2、tolI-Keller1*,E.Soulier1,C.Royer1,C.Thumann1,N.Brignon2,G.J.J.vanDoornum1.1ErasmusUniversityMedicalCentreN.Meyer2,I.Mello3,C.Pereira3,B.Ellero4,M.WoehI-Jaegle4,Rotterdam;2UniversityMedicalCentreUtrecht,TheNetherlandsC.Meyer4,D.Jaeck4,RWolf4,E.Schvoerer1.llnstitutdeVirologie,

3、2D~partementd'lnformationM~dicale,CHUdeStrasbourg,Aim:TheepidemiologiccharacteristicsofHCoV-NL63,HCoV-HKU1Strasbourg,France,31nstitutButantan,Virologie,SaoPaulo,Brazil,andHCoV-OC43andHCoV-229einadultandpaediatricpatients4Transplantation,CHUdeStrasbourg,Strasbourg,Francewerei

4、nvestigated.Furthermore,thegeneticvariabilityofHCoV-NL63andHCoV-OC43strainswasinvestigated.BackgroundandAims:LivercirrhosisrelatedtochronicinfectionMethods:Studieswereperformedonrespiratorysamplessub-byHCVisamainindicationforlivertransplantation(LT).AIIograftsmittedtotheViro

5、logyLaboratoryoftheErasmusMCforroutinearesystematicallyre-infectedwithHCVyetprognosisofinfectionrespiratoryvirusdetectionbetweenJune2004andJune2005.Sam-differsfrompatienttopatient.AhighrateofnucleotidemutationspleswereanalysedforthepresenceofhumancoronavirusesusingduringHCVr

6、eplication,adifferentialadaptationofviralstrainstothereal-timenucleicacidamplification.Patientrecordswerereviewedlivergraftandavariableefficiencyoftheimmuneresponsecouldforpatientstestedpositive.explainHCVrecurrence.Ininfectedpatients,HCVcirculatesasaResults:1376Samplesweres

7、ubmitted.70Coronaviruspositivemixtureofcloselyrelatedbutdistinctgenomescalledquasispecies.samples(5.1%)weredetectedfrom54patients:forHCoV-OC4340LittleinformationisavailableonchangesinHCVquasispeciesearlysamplesfrom31patients,forHCoV-229E1samplefrom1patient,followingtransplan

8、tation.forHCoV-NL6327samplesfrom23patientsandforHCoV-HKU1Methods:Seventeenp