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1、AcceptedManuscriptTMPRSS2:ApotentialtargetfortreatmentofinfluenzavirusandcoronavirusinfectionsLiWenShen,HuiJuanMao,YanLingWu,YoshimasaTanaka,WenZhangPII:S0300-9084(17)30187-6DOI:10.1016/j.biochi.2017.07.016Reference:BIOCHI5247Toappearin:BiochimieReceivedDate:18Apri

2、l2017RevisedDate:0300-90840300-9084AcceptedDate:31July2017Pleasecitethisarticleas:L.W.Shen,H.J.Mao,Y.L.Wu,Y.Tanaka,W.Zhang,TMPRSS2:Apotentialtargetfortreatmentofinfluenzavirusandcoronavirusinfections,Biochimie(2017),doi:10.1016/j.biochi.2017.07.016.ThisisaPDFfileof

3、anuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproducti

4、onprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTABSTRACT:Influenzavirusandcoronavirusepidemicsorpandemicshaveoccurredinsuccessionworldwidethroughouttheearly21stcentury.Theseepidemicsorpan

5、demicsposeamajorthreattohumanhealth.Here,weoutlineacriticalroleofthehostcellproteaseTMPRSS2ininfluenzavirusandcoronavirusinfectionsandhighlightanantiviraltherapeuticstrategytargetingTMPRSS2.MANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPTTMPRSS2:APotentialTargetforTreatmentofI

6、nfluenzaVirusandCoronavirusInfectionsaab,*ca,*LiWenShen,HuiJuanMao,YanLingWu,YoshimasaTanaka,WenZhangaLabofChemicalBiologyandMolecularDrugDesign,CollegeofPharmaceuticalScienceandInstituteofDrugDevelopment&ChemicalBiology,ZhejiangUniversityofTechnology,Hangzhou,3100

7、14,ChinabLabofMolecularImmunology,VirusInspectionDepartment,ZhejiangProvincialCenterforDiseaseControlandPrevention,Hangzhou,310051,ChinacCenterforInnovationinImmunoregulativeTechnologyandTherapeutics,GraduateSchoolofMedicine,KyotoUniversity,Kyoto,606-8501,Japan*Cor

8、respondingauthors:WenZHANG,LabofChemicalBiologyandMolecularDrugDesign,CollegeofPharmaceuticalScienceandInstituteofDrugDevelopment&ChemicalBiology