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1、VIRALIMMUNOLOGYVolume20,Number3,2007?MaryAnnLiebert,Inc.Pp.495–502DOI:10.1089/vim.2007.0038BriefReportProtectionfromInfectionwithSevereAcuteRespiratorySyndromeCoronavirusinaChineseHamsterModelbyEquineNeutralizingF(ab)2DEYANLUO,1,*BINGNI,2,3,*GUANGYUZHAO,1Z

2、HENGCAIJIA,2LILIZHOU,1MAREKPACAL,3LIANGYANZHANG,1SONGLEZHANG,1LIXING,1ZHIHUALIN,3LIWANG,2JINTAOLI,2YUNFEILIANG,2XINFUSHI,1TINGTINGZHAO,2LIYUNZOU,2YUZHANGWU,2andXILIANGWANG1ABSTRACTTowarrantpotentialclinicaltesting,theequineanti-severeacuterespiratorysyndrom

3、ecoronavirus(SARS-CoV)F(ab)2requiresevaluationinasmanyanimalmodelsaspossible.Inthisstudy,wees-tablishedanewanimalmodel,theChinesehamster,susceptibletoSARS-CoVinfection.SARS-CoVcouldpropagateeffectivelyandsustainhighlevelsfor1wkinanimallungs.Allanimalswerep

4、ro-tectedfromSARS-CoVinfectioninpreventivesettings.Further,whenusedtherapeuticallythisan-tibodyledtoanapproximately4-log10decreaseinviralburdenininfectedanimallungs.Thepatho-logicalchangesinlungscorrelatedcloselywiththedoseofantibodyadministered.Theexcellen

5、tpreventiveandtherapeuticrolesofequineanti-SARS-CoVF(ab)2inseveralanimalmodels,in-cludingthenovelChinesehamstermodeldescribedinthisstudy,haveprovidedexcitingdatacon-cerningitspotentialclinicalstudy.INTRODUCTIONhavealreadyshownpromisingresults(5–7),although

6、theywereusuallyusedempiricallyduringthe2002–2003THEPREVENTIONANDTREATMENTofsevereacuteres-SARSoutbreak.piratorysyndrome(SARS)includesseveralstrate-Passiveimmunityhaslongbeenusedinthepreventiongies,includingvaccinescurrentlyunderdevelopmentandtreatmentofinfe

7、ctiousdiseases(8).Thepracticeof(1–4),antiviraldrugs,andpassivetransferofantibodies.administeringpolyclonalimmunoglobulinsfromhyperim-Someantiviralagentssuchasinterferons,ribavirin,andmuneseraofanimalorhumanoriginhasacentury-oldhumanimmunodeficiencyvirus(HIV

8、)proteaseinhibitorshistoryofbeingeffectiveagainstsomeviruses(9–13),pro-1DepartmentofImmunology,InstituteofMicrobiologyandEpidemiology,AcademyofMilitaryMedicalSciences,Beijing,People’sRepublicofChina.2I