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1、ArchivfiirdiegesamteVirusforsehung4t,66--70(1973)9bySpringer-Verlag1973ProtectiveEffectofanInactivatedAvianCoronavirusVaccineAdministeredbyAerosolByM.F.Coma:NationalAnimalDiseaseLaboratory,NorthCentralRegion,Agriculturall~esearchService,U.S.DepartmentofAgriculture,Ames,Iowa,U.S.A.ReceivedO

2、ctober9,1972SummaryTheantigenicityandprotectiveeffectof3strainsofavianinfectiousbronchitisvirusinactivatedbybeta-propiolactonewerestudied.Chickensadministered2dosesoftheinactivatedConnecticutstrain(IBV-46)vaccinebyaerosolat3-weekintervalshadsignificantlevelsofvirus-neutralizingantibodiesand

3、wereresistanttoinfectionbytheMassachusettsstrain(IBV-41)asdeterminedbyvirusisolationattempts.AntibodylevelsinchickensgiveninactivatedIowa33andIowa609werenotsignificantandtheywerenotresistanttoinfectionbyIBV-41.1.IntroductionImmunitytoavianinfectiousbronchitis(AIB),ahighlycontagiousviralinfe

4、c-tionoftherespiratorytractofchickenshasbeenstudiedusingliveandinactivatedvirusvaccirres(6).Livevirusvaccinesareadministeredinthedrinkingwater(6)orbyanaerosol(7)andareknowntoinduceagoodimmuneresponseifusedproperly(15).Anaerosolofhigh-embryo-passagedAIBvirushasbeenreportedtoinduceapartialres

5、istancetoinfectionofthetrachea,whichwassuggestedtobealocaltissueimmunity(7).Recentevidenceindicatedlow-embryo-passagedAIBvirusvaccinesinduceagooddegreeofprotectionofthetracheaagainstinfec-tion(17).ChickensvaccinatedwithaBPL-inactivatedAIBvirusvaccinehavebeenreportedtohaveneitherdetectablele

6、velsofvirus-neutralizing(VN)antibodiesnorresistancetoinfection(1,8,14).However,morerecentevidenceshowsthataBPL-inactivatedAIBvirusvaccineadministeredbyanaerosolandconcurrentsubcutaneousinoculationinducedsignificantlevelsofVNantibodiesandaffordedagooddegreeofprotectionagainstinfection(4).Imm

7、unizationofthehumanrespiratorytractwithinactivatedinfluenzaA2I-IongKongvirus(13)andrhinovirustype13(ii),administeredbyanaerosol,indicatesthatasignificantprotectiveeffectwasobservedwhencomparedtoindividualsvaccinatedbysubcutaneousorintra-muscularroutes.CO