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1、GutMicrobesISSN:1949-0976(Print)1949-0984(Online)Journalhomepage:http://www.tandfonline.com/loi/kgmi20Type2diabetesandgutmicrobiome:attheintersectionofknownandunknownSmithaUpadhyaya&GautamBanerjeeTocitethisarticle:SmithaUpadhyaya&GautamBanerjee(2015)Type2diabetesandgutmicrobiome:attheintersectiono

2、fknownandunknown,GutMicrobes,6:2,85-92,DOI:10.1080/19490976.2015.1024918Tolinktothisarticle:http://dx.doi.org/10.1080/19490976.2015.1024918Publishedonline:22Apr2015.SubmityourarticletothisjournalArticleviews:87ViewrelatedarticlesViewCrossmarkdataCitingarticles:1ViewcitingarticlesFullTerms&Conditio

3、nsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=kgmi20Downloadby:[UniversityofWesternOntario]Date:13November2015,At:14:58REVIEWGutMicrobes6:2,85--92;March/April2015;?2015Taylor&FrancisGroup,LLCType2diabetesandgutmicrobiome:attheintersectionofknownandunk

4、nownSmithaUpadhyaya*andGautamBanerjeeUnileverResearchandDevelopment;Bangalore,IndiaAdditionalSearchTerms:dysbiosys,gutmetabolites,malnourishment,nutrition,obesityTheprevalenceofmetabolicsyndromeisincreasinginFigure1.Theprevalenceoftype2diabetesissimilarinpopu-rapidlyacrosstheglobe.Thoughtheprevale

5、nceofthelationofhighanduppermiddleincomecountries,buttheagediseaseissimilarinpopulationofuppermiddleincomeandgroupoftheaffectedpopulationislowerinpopulationoflowerhighincomecountries,theageofaffectedpopulationismiddleincomecountries,impactingtheeconomyofthecorre-lowerinuppermiddleincomecountries.T

6、hisisattributedtospondingcountries.1Inaddition,themortalityduetodiabetesisgeneticaswellaschanginglifestylefactors.Thecontributingsigni?cantlyhigherinpopulationoflowermiddleincomecoun-factorsfortype2diabetesrangefromgenetic/epigenetictriescomparedtohigherincomecountries(Fig.2).Itissuggesteddisposal

7、,intrauterinenutrition,dietarypatterntosedentarythatgeneticpredispositionisoneofthemajorcontributorsforlifestyle.Theroleofthegutmicrobiotainmetabolicdisordersisincreasinglygainingimportance.Severalstudieshavehigh