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《p53 Directly Represses Id2 to Inhibit the Proliferation of NeuralProgenitor Cellsp53直接抑制Id2抑制神經(jīng)增殖 祖細(xì)胞》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、TISSUE-SPECIFICSTEMCELLSp53DirectlyRepressesId2toInhibittheProliferationofNeuralProgenitorCellsa,ba,caa,bBRENTONR.PAOLELLA,MATTHEWC.HAVRDA,AKIOMANTANI,CHRISTINAM.WRAY,a,ca,b,cZHONGHUAZHANG,MARKA.ISRAELabcNorrisCottonCancerCenter,DepartmentofGenetics,andDepartmento
2、fPediatrics,DartmouthMedicalSchool,Hanover,NewHampshire,USAKeyWords.p53genes?Id2genes?Stemcell?CellproliferationABSTRACT(2/2)Neuralprogenitorcells(NPCs)havethecapacitytoprolif-typeNPCsphenocopiesthebehaviorofp53NPCsbyerateandgiverisetoallmajorcentralnervoussystemc
3、ellenhancingNPCproliferationandself-renewal.Interest-typesandrepresentapossiblecelloforiginingliomagene-ingly,p53directlybindstoaconservedsitewithintheId2sis.DeletionofthetumorsuppressorgeneTp53(p53)promotertomediatetheseeffects.Finally,wehaveidenti-resultsinincre
4、asedproliferationandself-renewalofNPCs?edelevatedId2expressioningliomacelllineswithandisacommongeneticmutationfoundinglioma.Wemutatedp53anddemonstratedthatconstitutiveexpressionhaveidenti?edinhibitorofDNAbinding2(Id2)asanovelofId2playsakeyroleintheproliferationofg
5、liomastem-targetgenedirectlyrepressedbyp53tomaintainnormallikecells.These?ndingsindicatethatId2functionsasa(2/2)NPCproliferation.p53NPCsexpresselevatedlevelsproproliferativegenethatantagonizesp53-mediatedcellofId2andsuppressionofId2expressionissuf?cienttoin-cycler
6、egulationinNPCsandmaycontributetothemalig-hibittheincreasedproliferationandself-renewalwhichnantproliferationofglioma-derivedtumorstemcells.resultsfromp53loss.ElevatedexpressionofId2inwild-STEMCELLS2011;29:1090–1101Disclosureofpotentialcon?ictsofinterestisfoundatt
7、heendofthisarticle.WehavestudiedtheeffectofTp53(p53)pathwaydisrup-INTRODUCTIONtioninNPCs.p53inactivationisthoughttobeanearlyeventingliomagenesis[12]andisestimatedtooccurin87%ofNeuralprogenitorcells(NPCs)residinginthesubventricularsuchtumors[13].Inheritedgermlinemu
8、tationswithinthep53zone(SVZ)ofadultmammalshavetheabilitytogiverisetogene,asseeninpatientswithLi-Fraumenisyndrome,resultallthreemajorcentralnervoussystem
