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1、CurrPathobiolRep(2015)3:183–192DOI10.1007/s40139-015-0077-zMATRIXPATHOBIOLOGY(YOUHUALIU,SECTIONEDITOR)KeyFibrogenicSignaling11WeichunHe?ChunsunDaiPublishedonline:5April2015óTheAuthor(s)2015.ThisarticleispublishedwithopenaccessatSpringerlink.comAbstractFibrosisisde?ne
2、dasanexcessiveaccumula-mayresultfromdiversecauses,itisgenerallythoughtthattionofextracellularmatrixcomponentsthatleadtotheaninitialinjuryactivatesarepairprocessthataimstore-destructionoforganarchitectureandimpairmentoforganstoretheoriginaltissuestructure,andthatafail
3、uretofunction.Moreover,?brosisisanintricateprocessat-delicatelyregulatethisprocessresultsinsustained?brob-tributabletoavarietyofinterlaced?brogenicsignalsandlastactivation,matrixdeposition,andtissuedevastationintrinsicmechanismsofactivationofmyo?broblasts.Be-[2].Fibr
4、osisispartofprogressivelychronicdiseasesiningthedominantmatrix-producingcellsinorgan?brosis,parenchymalorgansthroughoutthebody,andthe?broticmyo?broblastsmaybedifferentiatedfromvarioustypesofprocessplaysanessentialroleinthedeteriorationoftheseprecursorcells.Identi?cat
5、ionofthesignalpathwaysthatorgans[1??,3??,4].Feweffectivetherapiestohalttissueplayakeyroleinthepathogenesisof?broticdiseasesmay?brosis,ortoreverseit,areavailableinclinicalpracticesuggestpotentialtherapeutictargets.Here,weemphasize[5??].Consequently,itisimportanttothor
6、oughlyunder-severalintracellularsignalingpathwaysthatcontrolthestandthecellularandmolecularmechanismsof?broge-activationofmyo?broblastsandmatrixproduction.nesis,notonlytoacquirenovelinsightsintothepathogenesisofthe?broticprocess,butalsotofurtherKeywordsFibrosisSmad
7、Mitogen-activatedproteinexploitef?cientstrategiestotreatpatientswith?brotickinasePhosphoinositide3kinaseWnt/b-cateninSonicdisorders.hedgehogFibrogenesisisadynamicandprogressiveprocessinwhichnonresolvingin?ammationfollowingapersistentinjurysetsthestagefor?brosisand
8、triggerstheactivationIntroductionofmatrix-producingmyo?broblastsdifferentiatedfromavarietyofprecursorcelltypesthroughdifferentmecha
