《2型糖尿病并發(fā)骨質(zhì)疏松的相關(guān)危險因素分析》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、2型糖尿病并發(fā)骨質(zhì)疏松的相關(guān)危險因素分析作者：李小鳳，施秉銀，龐雅玲，王養(yǎng)維【摘要】　　目的分析2型糖尿病(T2DM)患者并發(fā)骨質(zhì)疏松后骨密度(BMD)的改變及相關(guān)因素，為早期診斷、早期防治糖尿病并發(fā)骨質(zhì)疏松提供理論依據(jù)。方法根據(jù)受試者的骨密度值將糖尿病患者分為骨質(zhì)疏松組和非骨質(zhì)疏松組，對比兩組T2DM患者的性別、年齡、體重指數(shù)(BMI)、糖尿病病程、空腹血糖(FPG)、糖化血紅蛋白(HbA1c)、空腹胰島素(FIns)、胰島素敏感指數(shù)(ISI)、尿白蛋白定量(ALb)、24h尿蛋白定量、血清鈣、磷和堿性磷酸酶(

2、ALP)等指標之間的差異，并進行相關(guān)性分析。結(jié)果骨質(zhì)疏松(OP)組與非OP組比較，OP組年齡大，病程長，體重指數(shù)低，骨密度低，堿性磷酸酶高，胰島素敏感指數(shù)低，糖化血紅蛋白高、空腹胰島素低、24h尿蛋白定量和尿白蛋白定量高，t檢驗有統(tǒng)計學(xué)差異(P<0.05)；而空腹血糖、血磷、血鈣值無統(tǒng)計學(xué)差異。T2DM患者的BMD與年齡、病程、糖化血紅蛋白、24h尿蛋白定量、Alb、ALP負相關(guān)，與BMI、ISI正相關(guān)；與血鈣、血磷、空腹血糖無相關(guān)性。結(jié)論高齡、低體重、病程長、血糖控制不良、胰島功能差、胰島素抵抗、高的血堿

3、性磷酸酶、糖尿病腎病都是糖尿病合并骨質(zhì)疏松的危險因素?！娟P(guān)鍵詞】2型糖尿?。还敲芏?；骨質(zhì)疏松；危險因素10　　ABSTRACT:ObjectiveToinvestigatethechangesofbonemineraldensity(BMD)inpatientswithtype2diabetes(T2DM)complicatedwithosteoporosis(OP)andanalyzethefactorsrelatedtodiabeticosteoporosis(DOP)soastoprovidetheoret

4、icalevidenceforearlydiagnosisandpreventionofosteoporosiscomplicatedwithT2DM.MethodsAccordingtotheirBMDvalues,patientsweredividedintoOPgroupandnonOPgroup.Thenwecompareddifferencesinsex,age,bodymassindex(BMI),diabetesduration,fastingplasmaglucose(FPG),glycosyl

5、atedhemoglobin(HbA1c),fastinginsulin(FIns),insulinsensitivityindex(ISI),quantitativeofurinaryalbumin(ALb),quantitativeofurinaryproteinin24hours,serumcalcium(Ca),phosphorus(P)andalkaliphosphataselevel(ALP),andmadecorrelationanalysis.ResultsComparedwiththoseinn

6、onOPgroup,patientsinOPgrouphadolderage,longerdiseasecourse,smallerbaricindex,lowerbonedensity,higheralkaliphosphatase,lowerinsulinsensitivityindex,higherglycosylatedhemoglobin,higherquantitativeofurinaryproteinin24hoursandurinarymicroprotein,whichweresignifi

7、cantlydifferentaccordingtottest(P<0.05).However,thelevelsoffastingplasmaglucose,serumphosphorus10andserumcalciumdidnotdifferobviously.BMDoftype2diabeteswasnegativelycorrelatedtoage,diseasecourse,glycosylatedhemoglobin,quantitativeofurinaryproteinin24hours

8、,ALbandALP,butpositivelycorrelatedtoBMIandISI,andhadnocorrelationwithserumcalcium,serumphosphorusandfastingplasmaglucose.ConclusionManyfactors,suchasolderage,lowbodyweight,longdurationoft